Current fertility research

Below you can read about our current projects.

Recent fertility research
Read about our recent fertility projects.

Fertility research publications
Read more about our fertility research publication.

 

Fertility research


Details of our ongoing research

Below you can read in a bit more detail about our current projects. Should you be interested in participating in any of our projects, or perhaps joining our Patient Research Advisory Board, which helps us focus on answering questions important to you, please contact us.

Endometrial scratch trial

Endometrial scratch

This research study is being conducted to find out if performing an endometrial scratch is beneficial for women undergoing IVF/ICSI for the first time.

An endometrial scratch is a simple routine outpatient procedure that involves taking a small amount of tissue from the lining of the womb (endometrium). It is thought that the process of scratching the lining of the womb may release certain chemicals that are important in helping the fertilised egg (embryo) to stick to the lining of the womb (implantation). Similar trials have used the same technique in women undergoing IVF/ICSI for the second or subsequent time with beneficial results.

The endometrial scratch trial plans to recruit 1044 women from ten IVF units in the UK. Each woman taking part in the trial will be randomly allocated to receive (intervention group) or not receive (control group) the endometrial scratch procedure. If you have the endometrial scratch you’ll require one additional visit to your IVF clinic for the procedure.

For further information on this trial please contact Sue Wellstead on 023 8120 6856 or susan.wellstead@uhs.nhs.uk.

E-freeze

E-Freeze

Patients at Complete Fertility are currently being asked to take part in a research study to find out which method of embryo transfer results in a higher healthy baby rate. IVF involves hormone injections to stimulate a woman’s ovaries to produce eggs which are then removed by a minor operation and mixed with sperm to create embryos in the laboratory. Usually these embryos are replaced within the uterus in 3 to 5 days. This is called fresh embryo transfer. Any remaining embryos are usually frozen so that they can be thawed and transferred at a later date if required – a process known as thawed frozen embryo transfer. Both forms of embryo transfer are commonly used as part of routine IVF treatment.

There have been some small studies, which suggest that using thawed frozen embryos may lead to improved pregnancy rates. This is because when frozen embryos are used, there is a delay in embryo transfer of between one and three months, allowing the excess of hormones of ovarian stimulation to wear off, giving the uterus time to return to its natural state. Only a few, small studies have been done so we don’t know which procedure is better. The E-Freeze study will compare these two procedures of embryo transfer in 1086 couples from IVF centres throughout the UK.

For more information on this study please contact Sue Wellstead on 023 8120 6856 or susan.wellstead@uhs.nhs.uk.